Several years following the events of Metal Slug 4, 5, and 3D, the Peregrine Falcon Strike Force, the SPARROWS, and the Ikari Warriors are once again on a search for General Morden and his army, this time on a giant island landfill that has been converted into a military fortress, in order to stop his latest coup d'état. The game was released in 2008 for Japan on July 22 and North America on November 28 by Ignition Entertainment.
It marks the first game in the main series that would be released without an arcade version. It is the seventh and final title in the main Metal Slug series. Metal Slug 7 is a run and gun video game developed by SNK Playmore for the Nintendo DS.